AIDS-Associated Viral Oncogenesis (Cancer Treatment and by Craig Meyers

By Craig Meyers

One of crucial features of AIDS is the lack of protecting immune functionality within the contaminated host which ends up in elevated occurrence of opportunistic infections and cancers. This publication in particular addresses viral-induced human cancers linked to AIDS and saw within the AIDS inhabitants. It addresses the categorical therapy required during this distinct inhabitants and the molecular biology of the causative viral agents.

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AIDS Malignancies 41 CLINICAL PRESENTATION OF MCD Patients with MCD often have constitutional symptoms of fever and fatigue. On physical examination, diffuse lymphadenopathy, hepatosplenomegaly, and peripheral edema may be encountered. Further laboratory examination may reveal cytopenia, hypergammaglobulinemia, hypoalbuminemia, and raised C-reactive protein. ,237 12 of 20 patients were treated with chemotherapy. Of the 12 patients, nine received vinblastine with resulting partial response with loss of constitutional symptoms and regression of lymphadenopathy.

The study consisted of 39 patients and antiretrovirals were not given until after the final cycle of chemotherapy. 99 Rituximab Kaplan and colleagues100 reported a randomized trial in the HAART era using CHOP versus CHOP and rituximab (anti-CD20 antibody) given with each cycle and with an additional three monthly doses after complete response was attained. Median event-free survival, approximately a year, was similar between both groups. 027). Up to 60% of deaths were in patients with a CD4 count of <50/mm3, and 40% occurred during the maintenance phase of rituximab.

Adapted from reference 38) HAART vs no HAART No HAART No HAART Most responders received antiretrovirals including protease inhibitor 3 patients received no HAART and 2 received AZT for <3 months 2. 35 McGowan and Shah43 were the first to describe a case of remission maintained for over 2 years in an individual who had PCNSL after treatment with HAART alone. Hoffmann and colleagues,44 in a retrospective analysis, showed that survival time of patients receiving HAART in addition to RT differed significantly from those receiving RT or palliative care alone.

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